PART 2: The Great Misunderstanding: Fluid retention… doesn’t make you gain weight, it makes you lose it.

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📅 Author: Sonia Suc

🧪 Signs in blood and urine due to active TCRs:

Biological clues of active TCRs. When the TCRs (Collecting Tubules of the Kidney) are active, the body gives very clear signals. One of the most obvious is oliguria, that is, a very low urine output, around 200 ml per day. This does not mean that the kidneys are failing, but that the body is deliberately retaining water in order to survive. It’s an ancestral mechanism. This excess fluid causes visible edema: swelling in eyelids, ankles, hands, wrists, neck, and instep. The stretching of the tissues can even generate pain due to pressure on the nerves.

Diuretics (natural or synthetic) do not work during this phase. Only when the conflict of uprooting is resolved and the person enters the PCL phase (Post Conflictolysis), the body begins to release that accumulated water.

📈 KEY INDICATORS

UREA: elevated in blood
CREATININE: elevated in blood
URIC ACID: elevated in blood
SWELLING, under-eye bags, joints, etc.
OLIGURIA (the person urinates very little)

UREA

During the Active Phase, blood levels of urea and creatinine rise. This does not indicate kidney failure, but a direct sign of active TCRs. And here comes something essential: during the AF (Active Phase) of the TCRs, metabolic waste is no longer eliminated due to a mechanical issue of obstruction, caused by the growing adenocarcinoma in the Tubules, with the goal of retaining as much fluid as possible to survive.

The secondary biological meaning as an effect of not eliminating metabolic waste —in this case urea— and keeping it in the blood, is to leave it available so that, in case it is needed during the repair phase of the TCRs, it can be reabsorbed in the tubules and converted into protein for the repair.

Urine retention (oliguria), which causes as an effect the elevation of urea levels in the blood (uremia), has a biological purpose: to store uremic substances in case the organism needs protein during a longer period of time. The recycling of urea into protein takes place at the level of the kidney’s collecting tubules (TCRs). Urea is recycled into protein, and sooner or later, the excess protein is broken down by metabolism into urea. And the cycle continues as long as protein is required in the repair phase.

Urea in the blood can serve as a source of nutrition when the body is very weakened by a strong conflict related to the kidney’s collecting tubules (TCRs).

If blood levels of urea and creatinine are normal, there are no active TCRs.

In clinical lab tests, normal blood values of urea (also called blood urea nitrogen or BUN in English) are usually:

Adult men and women: 10 to 50 mg/dL (milligrams per deciliter)

🔁 Urea Cycle Explained Step by Step

We consume proteins (meat, eggs, etc.)
They are broken down into amino acids
If there is excess, the body removes the amino group → releases nitrogen
The liver converts that nitrogen (toxic like ammonia) into urea, a non-toxic compound
Urea circulates in the blood and is eliminated by the kidneys
But if the TCRs are active, the urine is not eliminated and urea accumulates in the blood. This is strategic: later, during the PCL, the body will reuse that urea as raw material to rebuild tissues.

2. CREATININE

🌀 Creatine and Creatinine Cycle

Creatine is produced in the liver, pancreas, and kidneys from the amino acids: arginine, glycine, and methionine.
It is transported to the muscles, where it becomes phosphocreatine: rapid energy.
Part of the creatine is broken down into creatinine, a constant waste product proportional to muscle mass.
Creatinine is filtered by the kidneys and eliminated through urine.

📌 Key difference between urea and creatinine
With active TCRs, creatinine also increases, since urine is not excreted normally, making it impossible to eliminate the metabolic waste from the blood, which, when filtered in the kidney, is naturally eliminated through urine under normotonic conditions. But unlike urea, creatinine is not reused (it is always a waste and the body eliminates it daily between 1 and 2%): it is only a marker that the kidneys are not filtering normally and that there is an AF of TCR, it is not used for tissue regeneration.

3. URIC ACID

💥 The role of uric acid

Uric acid also rises when the TCRs are active. It is the result of the breakdown of purines (present in meat and cells). Since it cannot be properly eliminated through urine, its level rises in the blood, contributing to the temporary toxic state that the body tolerates until the biological conflict is resolved.

🔄 URIC ACID CYCLE

🥩 PROTEIN INTAKE
You eat meat, organs —mainly liver and kidney—, fish, seafood, legumes, etc.
These foods contain purines, which are nitrogenous components found in all cells.

🧬 METABOLISM IN THE BODY
Purines are broken down in the body.
The liver converts these residues into uric acid as a way to eliminate excess nitrogen.

🚽 ELIMINATION THROUGH THE KIDNEY
Uric acid circulates in the blood.
It is filtered by the kidneys and eliminated through urine.

🧬 URIC ACID AS ANTIOXIDANT
Although it is known for its link to gout or kidney problems, uric acid also fulfills an essential positive function:

✅ It is one of the most powerful antioxidants in the blood
It neutralizes free radicals (molecules that damage cells).
It protects cell membranes, DNA, and lipids from oxidative damage.
It defends the body in situations of cellular stress, inflammation, or trauma.

🧠 From the biological perspective
The increase of uric acid is not always pathological; many times it is an adaptive response to:

• Protect the body from greater tissue damage.
• Facilitate tissue repair (in PCL phases, especially articular or muscular).
• Reinforce the antioxidant system when there are prolonged conflicts or intense processes of cellular regeneration.

🔍 Key evolutionary fact
👉 In many mammals, uric acid is broken down by an enzyme called uricase.
🧬 In humans, that enzyme is inactive, which increases our uric acid levels naturally.

🧬 Animals that do NOT have uricase (and therefore retain uric acid in the blood like humans):

• Humans
• Great apes (chimpanzees, gorillas, orangutans)
• Some Old World monkeys

These animals lost the function of the uricase enzyme due to genetic mutation during evolution according to official science. The truth is that here we share something in common with the apes.
They cannot transform it into allantoin, as other mammals do.
🔬 This suggests that the body prioritized having more circulating uric acid as an antioxidant defense mechanism.

It could be proposed that the loss of the uricase enzyme —and the resulting retention of uric acid in humans and apes— contributed to greater longevity. Let’s break it down:

🧠 1. Uric acid as antioxidant

Uric acid is one of the most potent antioxidants in human plasma.
After losing the ability to produce vitamin C, our ancestors partially compensated for this loss by retaining uric acid, which protects the brain and DNA from oxidative damage.
📚 Johnson et al. (2009) argue that this mutation was advantageous because it helped conserve energy and protect the nervous system during times of food scarcity.

🧬 2. Possible relationship with longevity

Animals that retain uric acid (like humans and great apes) also tend to have larger brains and longer lives compared to animals of similar size.
It is proposed that uric acid may have helped preserve cognitive functions, reducing neuronal aging due to oxidation.

🔎 Comparative example:

• Rats and dogs (with uricase): live 2–15 years.
• Humans and chimpanzees (without uricase): live 40–80 years or more.

They have naturally higher levels of uric acid in their blood.

🔄 Integrative conclusion
Not all elevated uric acid is negative.
It is part of an intelligent system of defense and adaptation.
Its role as an endogenous antioxidant is complementary and sometimes more powerful than vitamin C.
In intense biological processes (conflicts, repair, wear), its elevated presence can be a sign of intense biological activity, not necessarily of disease.

Once the conflict of uprooting is resolved, which happens in the PCL:

💧 When the conflict is resolved:

• Diuresis increases (more urination)
• Urea, creatinine, and uric acid levels decrease
• The body deflates
• Pain diminishes

⚠️ Why is all this important?
Because if we misinterpret these symptoms, we may think there is a “kidney failure” and medicalize something that is actually a biological program with meaning. Knowing this changes everything: the goal is not to artificially lower the values, but to help the person resolve their conflict of uprooting.

🌱 This knowledge empowers.
We are not victims of a disease. We are protagonists of a biological solution that awaits understanding and support.

✨ To go deeper and learn how to identify these programs:
⬆️ Visit awakingproject.com
💬 Join the forums and share your experience
🎓 Sign up for the free training in NMG

🫀 Your body is not broken. It is trying to save you.